- E2EG
- Ear to Ear Grin
- ED
- Emotionally Disturbed
- EDP
- Emotionally Disturbed Person
- EIF
- Exercise In Futility
- EOB
- End Of Business
- EOD
- End Of Discussion
- EOF
- End Of File
- EOL
- End Of Lecture
- EOT
- End Of Thread (i.e., don't reply to this message)
- ES&D
- Eat Shit & Die
- ES<HI
- Eat Shit & Live To Hate It
- ESAD
- Eat Shit And Die
- ESAL
- Eat Shit And Live
- ESOSL
- Endless Snorts of Stupid Laughter
- ESP
- ESPecially (frequently just "esp.")
- ETA
- Estimated Time of Arrival
- ETLA
- Extended Three Letter Acronym
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